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Project information
Vztah struktury a funkce v signálováni fibroblastových růstových faktorů

Project Identification
GF21-26400K
Project Period
1/2021 - 12/2023
Investor / Pogramme / Project type
Czech Science Foundation
  • LA Grants
  • Lead Agency
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
University of Wroclaw

Fibroblast growth factors (FGFs) interact with four types of cell surface receptors (FGFRs) to deliver signals critical for development and functioning of mammalian organs. FGFs trigger proliferative, migrational, anti-apoptotic and metabolic signaling, representing an attractive therapeutic option for tissue regeneration, metabolic syndromes and aging. Such use is however complicated by our poor knowledge of the molecular basis of FGF signaling. How a particular FGF regulates diverse cell responses is not known, and is the subject of the proposal. We will study the structure-function relationship of FGFs by engineering four members of FGF family, FGF8, FGF9, FGF10 and FGF18. We will obtain mutants with increased thermal stability and modified ability to interact with FGFRs and heparan sulphate. These FGF variants will be tested in cells for their ability to activate different types of signaling. The proposed research will unravel structural and biophysical properties of FGFs, which drive the specific cell response.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being Sustainable Development Goal No. 5 – Gender equality Sustainable Development Goal No. 17 – Partnerships for the goals

Publications

Total number of publications: 6

2024

2023

2022

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