Project information
Minimizing freezing-induced acidity changes to ensure the stabilization of biochemicals

Project Identification
MUNI/IGA/0991/2021
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Science

Buffers are used to maintain a stable pH in biochemical and pharmaceutical samples; they, however, alter their capacities in the frozen state, leading to partial or full degradation and loss of compounds’ functions. This project aims to study and characterize the freezing-induced acidity changes in the most frequent biological buffers within their operational pH ranges, in the presence and absence of cryoprotectants. Relevant mitigation strategies to minimize the acidity jumps will be tested.

Publications

Total number of publications: 1


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