Project information
Essential transcription regulator Rta of Epstein-Barr virus - functional and structural implications for new antiviral strategy

Epstein-Barr virus is one of the most common human viruses that infects more than 90% of the world population and causes infectious mononucleosis. Replication and transcription activator (Rta) is essential for the EBV life cycle. Therefore, Rta targeting with small molecules presents potential in the fight against EBV-associated diseases. The proposed project unravels the first structural information to prepare the ground for future Rta structure determination and rational anti-EBV drug design.