Project information
Adsorption of bases, nucleosides, nucleotides and polynucleotides on electrods
- Project Identification
- IAA4004702
- Project Period
- 1/1997 - 12/1999
- Investor / Pogramme / Project type
-
Academy of Sciences of the Czech Republic
- Grants of distinctly investigative character focused on the sphere of research pursued at present particularly in the ASCR
- MU Faculty or unit
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Faculty of Science
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Vladimír Vetterl, DrSc.
The adsorption of nucleic acid bases, nucleosides, nucleotides and polynucleotides adsorbed at the surfaces of mercury, and graphite will be studied by the electrochemical impedance spectroscopy. The interactions between adsorbed bases can result in their two-dimensional (2-D) condensation and formation of a compact layer. The effect of solvent on the kinetic of 2-D condensation of nucleic acid bases and compounds used to facilitate anchoring of DNA in the scanning tunneling microscopy (SFM) will be studied. The interaction energies of nucleic acid bases in the comact layers will be calculated and the effect of methyl- and halofen substituents of bases on this energy and on the kinetic of adsorptopn and condensation will be determined. The experimental results will be compared with the quantum chemical calculations.
Publications
Total number of publications: 10
2007
-
Adsorption of oligonucleotides A10, A25, A50 and A80 at the mercury/electrolyte interface.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, year: 2007, volume: 295, edition: March
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Low-frequency magnetic field effect on cytoskeleton and chromatin
Bioelectrochemistry, year: 2007, volume: 70, edition: 1
2005
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Effects of 50 Hz magnetic fields on the viability of different bacterial strains.
Electromagnetic Biology and Medicine, year: 2005, volume: 24, edition: 3
2002
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Electrochemical analysis of nucleic acids.
Year: 2002, number of pages: 66 s.
2000
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Adsorptive Stripping Analysis of DNA with Admittance Detection
Electroanalysis, year: 2000, volume: 12, edition: 12
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Nucleic acid sensing by impedance measurements
Electrochimica Acta, year: 2000, volume: 45, edition: 18
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Structure and stability of cytidine adlayers at the Hg electrode and carbone electrode covered with a mercury film.
Book of Abstracts, 51.ISE Meeting "Electrochemistry at the Turn of Millenium", year: 2000
1998
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Adsorption and condensation of xanthine at the mercury/solution interface.
Collections of Czechoslovac Chemical Communications, year: 1998, volume: 63, edition: 1
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Adsorption of single-stranded and double-helical polyadenylic acid at the mercury drop electrode.
Bioelectrochemistry and Bioenergetics, year: 1998, volume: 46, edition: 1
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Molecular dynamics of hemiprotonated intercalated four-stranded i-DNA: stable trajectories on a nanosecond scale
The Journal of the American Chemical Society, year: 1998, volume: roč. 120, edition: 24