Project information
Development of new diagnostic teniques for oncology
- Project Identification
- IBS5004010
- Project Period
- 1/2000 - 1/2004
- Investor / Pogramme / Project type
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Academy of Sciences of the Czech Republic
- Programme of Targeted Research and Development Support
- MU Faculty or unit
- Faculty of Informatics
- Cooperating Organization
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Institute of Biophysics
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
The project is directed to the improvement of diagnostic techniques in oncology both in primary diseases and in related infections. The development of high-resolution cytometric techniques and methods of the detection of the telomerase activity will be the goals of the project. Topographic characteristics of appropriate genetic loci in selected tumour tissues will be mesured and correlated to tumour characteristcs. The development of techniques and methods for clinical applications will be followed by industrial development of a confocal cytometr. In addition, methods of detection of the telomerase activity and expresion will be optimised both for the diagnostic purposes, and for testing the sensitivity of cultured tumor cells to cytostatics and potential cytostatic agents. The improvement of diagnostic techniques of fungal infections typical of oncological patients will be the additional goal of the project. DNA probes will be prepared for clinica diagnostics.
Publications
Total number of publications: 54
2004
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Automated acquisition and processing of multidimensional image data in confocal in vivo microscopy
Microscopy research and technique, year: 2004, volume: 64, edition: 2
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Automated confocal microscopy: The way of achieving both quality and quantity in 3D image cytometry
International Symposium on Biomedical Imaging, year: 2004
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Automated confocal microscopy: The way of achieving both quality and quantity in 3D image cytometry
Year: 2004, type:
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Automated image analysis in fluorescence microscopy: From isolated cells to tissues and microarray images
Biophysics of the Genome, year: 2004
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Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells
Biophysics of the Genome, year: 2004
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Different nuclear localization of aberrant and normal chromosome 8 homologues in intact or NaBt differentiated HT-29 cells
Biophysics of the Genome, year: 2004
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Dynamics of HP1 transgene loci movement and silencing in living cells
Biophysics of the Genome, year: 2004
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From Jenalumar to Ultrafast Microscopy of Living Cells
Biophysics of the Genome, year: 2004
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Image analysis of the movement of sub-cellular structures
Biophysics of the Genome, year: 2004
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Rapid Image Acquisition of Living Cells and its Limits
Biophysics of the Genome, year: 2004