Project information
Zdenek Andrysik Research Group: Molecular Mechanisms of Cancer

The scientific program of the research group is designed to accomplish the mission of the laboratory: to save lives through research of transcription factors (TFs) involved in carcinogenesis and identification of the treatment opportunities represented by targeting TFs. Cancer occurs from genetic and epigenetic
alterations resulting in deregulated transcriptional programs2, which are associated with virtually all hallmarks of cancer3. Aberrant activity of TFs constitutes cancer dependency and earmarks TFs as targets in the treatment of particular malignancies, such as cancers dependent on nuclear hormone receptors4. Acting both as oncogenes and tumor suppressors, TFs are no longer considered as “undruggable”5,6 as ever-increasing portfolio of compounds is available for research and treatment applications while novel technologies increase drug specificity7. Taken together, TFs represent a prime target for designing innovative treatment strategies and facilitating personalized medicine.