FH-EARLY will enable new strategies for earlier diagnosis and co-management of familial hypercholesterolemia . The project works with FH families with inherited cholesterol: parents, children (7-12), teenagers (13-18) and carers to co-create and test solutions. The three interrelated solutions are: a new chip array, enabling easier, cheaper and earlier diagnosis; a signature biomarker assay that provides unique risk stratification and personalized treatment strategies to FH and general population; an integrative precision health profiling (iPHP) tool using explainable AI to model well-defined data flows from multi-modal data in several patient cohorts across Europe. FH-EARLY will help prevent premature coronary heart disease, not only for FH patients, but also within the general population: with potential to generate considerable economic and social benefits.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.