Project information
Molecular genetic aspects of proarrhythmic of non-antiarrhythmic drugs
- Project Identification
- NA7424
- Project Period
- 1/2003 - 12/2005
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- R&D of Cardiovascular Diseases
- MU Faculty or unit
- Faculty of Science
- Keywords
- proarrhyhtmia; QT interval; torsade de pointes; gene; mutation; long QT syndrome
- Cooperating Organization
-
University Hospital Brno-Bohunice
- Responsible person prof. MUDr. Tomáš Novotný, Ph.D.
QT interval prolongation and increased risk of sudden death are adverse effects of long list of widely used drugs. The fenomenon has been called the acquired long QT syndrome and its mechanism remains unclear. The congenital long QT syndrome is underlain by cardiac ion channel genes. Mutational analysis of these genes in cases of proarrhythmia will contribute to understanding of arrhythmogenesis.
Results
The project assessed the occurence of proarrhythmia (by QT interval monitoring) and its molecular-genetic aspects. The occurence of drug-induced QT prolongation was lower than in literature. In 1 patient with prolonged QT a KCNQ1 gene mutation was found.
Publications
Total number of publications: 3
2007
-
Monitoring of QT interval in patients treated with psychotropis drugs
International Journal of Cardiology, year: 2007, volume: 117, edition: 3
2005
-
Snášenlivost a bezpečnost antipsychotik druhé a třetí generace
Česká a slovenská psychiatrie, year: 2005, volume: 101, edition: 2
-
The occurence of QTC prolongation in patients treated with psychopharmacs
Book abstract XIII. Word congress of psychiatry, year: 2005