Project information
Biologically Active Organic Compounds Interacting with Adenine-binding Proteins
(bioactivecpds)
- Project Identification
- 230936
- Project Period
- 1/2010 - 4/2015
- Investor / Pogramme / Project type
-
European Union
- 7th Specific RTD Programme
- People
- MU Faculty or unit
- Faculty of Science
Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases. The structures contain heterocyclic cores relatively unknown in the literature and will mimic interactions of purine-containing biological substrates (especially ATP) with proteins that are relevant in oncology. The compounds will be synthesized by modern methods of organic synthesis, namely by ring-closing metathesis and will be profiled in biological asssays that include diverse biological targets, especially those that are relevant to the treatment of cancer.
Publications
Total number of publications: 2
2015
-
Substituované furo[3,2-b]pyridiny pro použití jako léčiva
Publisher: Úřad průmyslového vlastnictví, state: Czech Republic, patent's number: 305472, year: 2015
2013
-
Quantum Mechanical Scoring: Structural and Energetic Insights into Cyclin-Dependent Kinase 2 Inhibition by Pyrazolo[1,5-a]pyrimidines
Current Computer-Aided Drug Design, year: 2013, volume: 9, edition: 1