Project information
Biologically Active Organic Compounds Interacting with Adenine-binding Proteins (bioactivecpds)

Investor logo
Project Identification
230936
Project Period
1/2010 - 4/2015
Investor / Pogramme / Project type
European Union
MU Faculty or unit
Faculty of Science

Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases. The structures contain heterocyclic cores relatively unknown in the literature and will mimic interactions of purine-containing biological substrates (especially ATP) with proteins that are relevant in oncology. The compounds will be synthesized by modern methods of organic synthesis, namely by ring-closing metathesis and will be profiled in biological asssays that include diverse biological targets, especially those that are relevant to the treatment of cancer.

Publications

Total number of publications: 2


You are running an old browser version. We recommend updating your browser to its latest version.

More info