Publication details
Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | International Journal of Electrochemical Science |
| MU Faculty or unit | |
| Citation | |
| Field | Physical chemistry and theoretical chemistry |
| Keywords | Medicinal Chemistry; Nucleic Acid Interaction; Electrochemistry; Cyclic Voltammetry; Differential Pulse Voltammetry; Copper; Lawsone |
| Description | Metal complexes of fungal and plant secondary metabolites are in the centre of interest, especially due to their biological properties including cytotoxicity. In our work, we focused on electrochemical behaviour of seven newly prepared ternary copper(II) complexes of lawsone with additional O-donor (water) and N-donor ligands (pyridine, 2-, 3-, and 4-aminopyridine, 3-hydroxypyridine, and 3,5-dimethylpyrazole) using the methods of cyclic voltammetry and differential pulse voltammetry. In addition, we tested ability of these complexes to interact with DNA. Our results indicate that the most simple complex of lawsone - Cu(lawsone)(2)(H2O)(2)center dot 0.5H(2)O proved significant prooxidant properties, which may contribute to its cytotoxicity that has been demonstrated in recent literature. In addition, all complexes evidenced ability to interact with dsDNA. In article, possible mechanisms of these interactions are discussed. |