Publication details

ANALYSIS OF MICRO RNAS EXPRESSION IN CELL LINES DERIVED FROM PROSTATE CARCINOMA

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Authors

HUDCOVÁ Kristýna RAUDENSKÁ Martina HLAVNA Marián GUMULEC Jaromír SZTALMACHOVÁ Markéta TANHÄUSEROVÁ Veronika BABULA Petr ADAM Vojtěch KIZEK René MASAŘÍK Michal

Year of publication 2012
Type Conference abstract
Citation
Description MiRNAs constitute a large class of single-stranded RNA molecules of 19 to 25 nucleotides that are involved in post-transcriptional gene silencing. MiRNAs not only regulate various developmental and physiologic processes but also are involved in cancer development and can play a role as an important biomarkers. The aim of this study was to determinate the expression levels of selected miRNA in the non-tumor PNT1A line in comparison with tumor lines 22Rv1, PC-3, and LNCaP. We used the TaqMan Gene Expression Assays and quantitative RT-PCR. We observed significantly higher (p<0.01) expression of miRNA 23a in all tumor lines compared to non-tumor PNT1A. Significantly higher (p<0.01) expression of miRNA 224 in 22Rv1 line compared to others and significantly higher (p<0.01) expression of miRNA 375 in all tumor lines in comparison with non-tumor PNT1A.
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