Publication details
Sarkosin v moči pacientů se zhoubným nádorem prostaty
| Title in English | Sarkosin in the urine of patients diagnosed with prostate cancer |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Praktický lékař |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | tumour marker; prostata cancer; high performance liquid chromatography (HPLC) |
| Attached files | |
| Description | Prostate specific antigen (PSA) is currently the most important marker for prostate cancer, but still belongs to markers where is the necessity to disrupt damaged tissue. Therefore, markers, through which it would be possible to identify prostate cancer by analysis of urine are being looked for. Non-protein amino acid sarcosine is one of the substances whose potential could be used in the diagnosis of prostate cancer from urine. According to several studies, sarcosine is rated as significantly better marker of developing prostate cancer than PSA and therefore the aim of this study was to optimize a simple test for sarcosine in the urine of patients diagnosed with prostate cancer and healthy controls. For determ1nation of sarcosine, there were used 55 male urine semples, 23 controls and 32 patients. In this study, we confirmed that the concentration of sarcosine were determinable (within the range from 120 to 1500 microM with average of 505 microM in urine samples of patients diagnosed with prostate cancer. Sarcosine concentrations in healthy subjects were below detection limit of the method. The obtained positive results suggest that detection of sarcosine might have a potential in the diagnosis of prostate cencer. |