Uric acid, allopurinol therapy, and mortality in patients with acute heart failure — results of the Acute HEart FAilure Database registry

• Authors: MÁLEK Filip; OŠŤÁDAL Petr; PAŘENICA Jiří; JARKOVSKÝ Jiří; VÍTOVEC Jiří; WIDIMSKÝ Petr; LINHART Aleš; FEDORCO Marián; COUFAL Zdeněk; MIKLÍK Roman; KRŰGER Andreas; VONDRAKOVÁ Dagmar; ŠPINAR Jindřich
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Journal of Critical Care
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.jcrc.2012.03.011
• Field: Cardiovascular diseases incl. cardiosurgery
• Keywords: Uric acid; Acute heart failure; Allopurinol; Mortality
• Description: Study Objective: The aim of this study was to explore the prognostic role of serum uric acid (UA) measurement in the hospital and long-term mortality assessment in subjects with acute heart failure (AHF) from the Acute HEart FAilure Database registry (AHEAD). The AHEAD registry comprised 4153 patients with AHF syndromes hospitalized at the AHEAD participating centers. Patients and Methods: The study included 1255 patients who were admitted to the AHEAD participating centers with acute decompensated chronic heart failure, de novo heart failure, or cardiogenic shock between September 2006 and October 2009 and who had information about serum UA concentration available at the time of hospital admission. The hospital and long-term mortality was followed using the centralized database of the Ministry of Health, Czech Republic.

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