Publication details

Validita a prediktivní hodnota skríningových testů u prediabetické a časné diabetické polyneuropatie

Title in English Validity and predictive value of screening tests in prediabetic and early diabetic polyneuropathy
Authors

DIVIŠOVÁ Šárka VLČKOVÁ Eva HNOJČÍKOVÁ Mária NĚMEC Martin DUBOVÝ Petr DUŠEK Ladislav JARKOVSKÝ Jiří BĚLOBRÁDKOVÁ Jana BEDNAŘÍK Josef

Year of publication 2012
Type Article in Periodical
Magazine / Source Česká a slovenská neurologie a neurochirurgie
MU Faculty or unit

Faculty of Medicine

Citation
Field Neurology, neurosurgery, neurosciences
Keywords prediabetes; type 2 diabetes mellitus; small-fiber neuropathy; large-fiber neuropathy; early diabetic neuropathy
Description Aim: To confirm the validity and predictive value of selected screening tests for neuropathy The Michigan Neuropathy Screening Instrument (MNSI) and The Utah Early Neuropathy Scale (UENS), and a screening test for detection of neuropathic pain - DN4 - in a population of patients with prediabetes and early type 2 diabetes mellitus (preDM/eDM2). Conclusions: DN4 is able to discriminate patients with and without DPNP; the recommended cut-off values, however, provide high specificity but low sensitivity (i.e. attributes typical for a confirmatory, not a screening test). MNSI I discriminated patients with clinically-based SFN, although not when the recommended cut-off value of >7 points was used. Both MNSI II and UENS reliably discriminated preDM/eDM2 patients with and without LFN while only UENS discriminated patients with and without clinically-based SEN. Neither test was useful for detection of laboratory-based SFN.
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