Publication details
Asociace polymorfizmů v genu pro matrix metalloproteinázu-2 a tkáňový inhibitor metalloproteinázy-2 s roztroušenou sklerózou
| Title in English | An association between matrix metalloproteinase-2 and TIMP-2 +853G/A gene polymorphisms and multiple sclerosis |
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| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská neurologie a neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | gene polymorphism; matrix metalloproteinases; multiple sclerosis |
| Description | Background: Matrix metalloproteinases (MMPs) play an important role in the immunopathogenesis of multiple sclerosis (MS). They are notable contributors to the progression of inflammatory process, blood-brain barrier disruption, formation of MS lesions and demyelination. The matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase-2 (MMP-2) are the most important. They are expressed by T-lymphocytes and monocytes, the predominant group of inflammatory cells in active demyelinating plaques. In our previous study, we demonstrated a borderline association of MMP-2-1575G/A gene polymorphism with MS susceptibility. To date, no other genetic association study involving MMP-2 and (tissue inhibitor of metalloproteinases-2 (TIMP-2) genes variability and MS have been carried out. Results: We demonstrated a borderline association between TIMP-2 +853G/A gene polymorphism and a risk of developing relapsing-remitting MS (Pg = 0.04), odds ratio (OR), 1.46; 95% confidence interval (Cl): 0.91-2.36). Other polymorphisms were associated neither with MS susceptibility nor with the disease phenotype. No association with disability was found. Conclusion: MMP-2 and TIMP-2 gene polymorphisms are not a risk factor for MS susceptibility in the Czech population. |