Publication details

MDR1 in Paroxetine-Induced Sexual Dysfunction

Authors

ŽOURKOVÁ Alexandra SLANAŘ Ondřej JARKOVSKÝ Jiří PALČÍKOVÁ Ivana PINDUROVÁ Eva CVANOVÁ Michaela

Year of publication 2013
Type Article in Periodical
Magazine / Source Journal of Sex and Marital Therapy
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.tandfonline.com/doi/pdf/10.1080/0092623X.2012.668514
Doi http://dx.doi.org/10.1080/0092623X.2012.668514
Field Genetics and molecular biology
Keywords P-GLYCOPROTEIN; MDR1; Sexual Dysfunction
Description Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).

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