Publication details

Prostatický specifický antigen, metalothionein a caveolin-1 jako markery vzniku a rozvoje karcinomu prostaty

Title in English Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom
Authors

SZTALMACHOVÁ Markéta GUMULEC Jaromír CERNEI Natalia Vladimirovna HLAVNA Marián ZÍTKA Ondřej BABULA Petr ADAM Vojtěch KIZEK René MASAŘÍK Michal

Year of publication 2012
Type Article in Periodical
Magazine / Source Chemické listy
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.chemicke-listy.cz/docs/full/2012_11_1075-1080.pdf
Doi http://dx.doi.org/10.1039/c2ib00157h
Field Biochemistry
Keywords prostate cancer;metallothionein;prostatic specific antigen;caveolin-1
Description The current diagnostic limitations of prostate cancer have shown that the development of new approaches to early detection of aggressive forms of of the cancer is very important. A comprehensive approach to detection of potential tumour markers using different methods and their optimization is described. We focused on caveolin-1 and metallothionein and the obtained results were compared with prostate specific antigen as a golden standard of prostate cancer markers. All the mentioned markers were detected on both the mRNA and protein levels in three types of prostate cell lines. Metallothionein and caveolin-1 rank among the promising markers in prostate cancer diagnosis, especially. for distinguishing aggressive silent forms of the disease.

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