Publication details
Pokroky ve farmakoterapii kostních sarkomů
| Title in English | Recent advances in treatment of bone sarcomas |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Onkologie |
| MU Faculty or unit | |
| Citation | |
| web | http://www.onkologiecs.cz/pdfs/xon/2012/04/06.pdf |
| Field | Oncology and hematology |
| Keywords | sarcoma; targeted therapy; angiogenesis; giant bone cell tumor; metronomic therapy |
| Description | At present, therapy success in bone sarcoma is significantly better compared to historical cohorts, with 60–70 % overall survival. Unfortunately, no sufficient progress in better survival of patients with relapsed and refractory bone sarcomas during last twenty years has been observed. Here we review targeted therapeutics in bone sarcomas being under investigation that may bring chance to patients suffering from relapsed and chemoresistant bone sarcomas. A majority of the targeted drugs are given as part of phase 1 or 2 studies. Separately, recent successful findings of efficacy of denosumab in treatment of giant bone cell tumor are described. |