Publication details

Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium

Authors	COTE Michele L. LIU Mei BONASSI Stefano NERI Monica SCHWARTZ Ann G. CHRISTIANI David C. SPITZ Margaret R. MUSCAT Joshua E. RENNERT Gad ABEN Katja K. ANDREW Angeline S. BENCKO Vladimir BICKEBOELLER Heike BOFFETTA Paolo BRENNAN Paul BRENNER Hermann DUELL Eric J. FABIANOVA Eleonora FIELD John K. FORETOVÁ Lenka FRIIS Soren HARRIS Curtis C. HOLCATOVA Ivana HONG Yun-Chul ISLA Dolores JANOUT Vladimir KIEMENEY Lambertus A. KIYOHARA Chikako LAN Qing LAZARUS Philip LISSOWSKA Jolanta LE MARCHAND Loic MATES Dana MATSUO Keitaro MAYORDOMO Jose I. MCLAUGHLIN John R. MORGENSTERN Hal MUEELLER Heiko ORLOW Irene PARK Bernard J. PINCHEV Mila RAJI Olaide Y. RENNERT Hedy S. RUDNAI Peter SEOW Adeline STUCKER Isabelle SZESZENIA-DABROWSKA Neonila TEARE M. Dawn TJONNELAN Anne UGOLINI Donatella VAN DER HEIJDEN Henricus F. M. WICHMANN Erich WIENCKE John K. WOLL Penella J. YANG Ping ZARIDZE David ZHANG Zuo-Feng ETZEL Carol J. HUNG Rayjean J.
Year of publication	2012
Type	Article in Periodical
Magazine / Source	European Journal of Cancer
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1016/j.ejca.2012.01.038
Field	Oncology and hematology
Keywords	Lung cancer; Familial aggregation
Description	Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group. (c) 2012 Elsevier Ltd. All rights reserved.