Publication details
Cholelitiáza a nefrolitiáza v průběhu léčby ceftriaxonem
| Title in English | Ceftriaxone associated cholelithiasis and urolithiasis |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Pediatrie pro praxi |
| MU Faculty or unit | |
| Citation | |
| Field | Paediatry |
| Keywords | ceftriaxone; pseudocholelithiasis; nephrolithiasis; hypercalciuria |
| Description | Ceftriaxone is a widely used third-generation cephalosporin that is generally considered very safe, but complications such as cholelithiasis (the prefer term is pseudocholelithiasis), and rarely, nephrolithiasis have been reported in children. Despite several trials, the mechanisms underlying the formation of ceftriaxone-associated pseudocholelithiasis and/or nephrolithiasis remain unclear. We here report a 8-year old boy with aseptic meningoencephalitis complicated by pseudocholelithiasis and nephrolithiasis on the 6th day of treatment with ceftriaxone. During treatment with ceftriaxone was diagnosed hypercalciuria. Ceftriaxone associated pseudocholelithiasis and nephrolithiasis are transitory and usually without complications. In all patients who receive ceftriaxone is very important frequent ultrasound examination of kidney and urinary/biliary tracts. It is therefore worthwhile to monitor the levels of urinary calcium to creatinine ratio in patients on ceftriaxone, as they may be at greater risk for developing large stones and renal damage. |