Publication details

Pharmaco-mechanic antithrombotic strategies to reperfusion of the infarct-related artery in patients with ST-elevation acute myocardial infarctions

Authors

KALA Petr MIKLÍK Roman

Year of publication 2013
Type Article in Periodical
Magazine / Source Journal of Cardiovascular Translational Research
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1007/s12265-013-9448-1
Field Cardiovascular diseases incl. cardiosurgery
Keywords Acute myocardial infarction; Antiplatelet therapy; STEMI; Thrombectomy; Thrombus management
Attached files
Description Primary percutaneous coronary intervention is the best treatment of patients with ST elevation myocardial infarction (STEMI). When managing a STEMI patient, our approach must be rapid and aggresive in order to interrupt the pathological process of thrombus formation and stabilization. The therapy must be initiated prior to angiography (pretreatment), continued during the procedure (periprocedural), recovery phase (in-hospital), and follow-up. The treatment strategies resulting in thrombus dissolution/extraction have focused on optimization of both pharmacological and interventional therapies. At present, there is no optimal evidence-based approach to all patients with STEMI, and the treatment of these patients needs to be modified with respect to the risk profile, availability of medical resources, and our experience. In this review, we summarize current pharmacological and interventional strategies used in the setting of STEMI and discuss potential benefits of novel dosing regimens and combinations of drugs and techniques.

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