Publication details
18F-FDG PET a PET/CT vyšetření v časné diagnostice obrovskobuněčné arteritidy - soubor 39 pacientů
| Title in English | 18F-FDG PET and PET/CT examinations in early diagnosis of giant cell arterisis - a cohort of 39 patients |
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| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Česká radiologie |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | giant cell arteritis; temporal arteritis; large vessel vasculitis; fever of unknown origin; PET; PET/CT |
| Attached files | |
| Description | Giant cell arteritis is classified among large-vessel vasculitis. Its first manifestation may be a febrile state with elevation in inflammation markers (ESR, CRP) and for examinations of such patients it is possible to use PET (PET/CT) scanning. Aim. To verify if high FDG uptake in the walls of large vessels is corresponding with giant cell arteritis. Method. Based on PET (25 pts) and PET/ CT (14 pts) examinations, 39 patients with suspicion of large-vessel vasculitis formed a cohort in which were 30 males and 9 females aged 45-81 with a mean age of 64.9 and median of 65 years. For verifying, a direct proof using histologie examination of a vessel excision (4 pts) or an indirect one - a therapeutic test for ESR and CRP decreases during corticotherapy in immunosuppressive doses (39 pts) were opted. FDG uptake was measured in 7 vessel areas with an area evaluated as positive when it surpassed an uptake of the liver parenchyma. As a control group a sample of 100 patients free from vasculitis was used. For comparison, results from further imaging examinations were used. Results. Giant cell arteritis was proved in 3 from 4 histologie examinations. By indirect testing, vasculitis in all 39 patients was confirmed. In patients with vasculitis before the use of corticotherapy, positivity of at least 3 vessel areas was found, whereas in the control group positivity was observed in 0-2 vessel areas. Further imaging examinations did not detect clear symptoms of vasculitis, it could be evaluated as abnormal. Conclusion. The finding of generalized high FDG uptake in large vessels in patients with symptoms of active inflammatory disease gave evidence for large-vessel vasculitis. The PET (PET/CT) examinations detected the disease in its early phase and also determined the extent thereof. Direct imaging of afflicted temporal vessels was successful only by using a hybrid PET/CT scanner. |