Publication details
The case of Stevens-Johnson syndrome/toxic epidermal necrolysis after nimesulide treated with intravenous immunoglobulin
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| Year of publication | 2013 |
| Type | Appeared in Conference without Proceedings |
| Citation | |
| Description | The report describes a serious adverse drug reaction - Stevens-Johnson syndrome/toxic epidermal necrolysis after the peroral use of one standard dose of medicine containing nimesulide. The patient had a history of allergy to nimesulide, which was an active suůbstance in other medical product having a different commercial name. The Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the most severe cutaneous and mucosal reactions with low incidence and high morbidity and mortality, usually induced by drugs. The treatment is based on symptomatic therapy similar to the therapy of patients with burns. High-dosed intravenous immunoglobulin (IVIG) and glucocorticoids belong to the most often used therapeutic possibilities. The 85-year-old woman with generalized drug eruption, lasting about one week, with formation of flaccid blisters and erosions. About 20% of body surface area was affected the diagnosis of SJS/TEN overlap was determined. The trigger factor was one tablet on nimesulide. IVIG and high-dose glucocorticoids were used to stop the progression. The IVIG were administered in a dose of 0,45 g/kg fractionated over a period of three days. After 21 days 80% of erosions were epitelized and the patient was in a goog vital status. |