Publication details
Vliv klinických a molekulárních faktorů na odhad rekurence kolorektálních adenomů u dlouhodobě sledovaných pacientů
| Title in English | Impact of clinical and molecular factors on the estimation of colorectal adenomatous polyps recurrence in long-term clinical follow-up patients |
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| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Gastroenterologie a hepatologie |
| MU Faculty or unit | |
| Citation | |
| Field | Other medical specializations |
| Keywords | colorectal neoplasms; adenoma; cancerogenesis; DNA copy number variations |
| Description | Colorectal neoplasms development stages (adenomas) are determined by histopathological staging assessing the risk level of cancer development. Colorectal adenomas recurrence increases the requirements for patients’ follow-up. The malignant transformation process of the normal tissue is accompanied by characteristic changes of the level of genetic and epigenetic disorders. The main study objective was a long-term (6–11 years) monitoring of patients after endoscopic polypectomy, mainly in relation to the presence of recurrent adenomas. Another goal was to study the genetic profile of the most common somatic DNA copy number variations and their possible relation to adenoma histopathology characteristics. Material and methods: Patients included in the study went through a colonoscopy examination with their adenomas removed in the period of 2002–2006. A standard specimen histopathology examination was carried out and correlated with the examination of a selected panel of somatic mutations (genes APC, TP53, KRAS and BRAF), which are typical for sporadic colorectal cancers. A sub-group of patients was followed up by colonoscopy in recommended intervals with a focus on the relation between the removed adenoma mutation and the presence of recurrent adenomas in the interval a) |