Syntheses of 5´-amino-2´,5´-dideoxy-2´,2´-difluorocytidine derivatives as novel anticancer nucleoside analogs

• Authors: LABROLI Marc A.; DWYER Michael P.; POPOVICI-MULLER Janeta; PU Qinglin; RICHARD Judson; ROSNER Kristen; PARUCH Kamil; GUZI Timothy J.
• Year of publication: 2014
• Type: Article in Periodical
• Magazine / Source: Tetrahedron Letters
• MU Faculty or unit: Faculty of Science
• Doi: http://dx.doi.org/10.1016/j.tetlet.2013.11.018
• Field: Genetics and molecular biology
• Keywords: Nucleoside; Gemcitabine; Reductive amination; Anticancer
• Description: A novel class of 5-amino-2,5-dideoxy-2,2-difluorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several synthetic routes were devised and implemented which relied upon either SN2 displacement or reductive amination to provide the desired derivatives.