Publication details
Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Biochemistry & Molecular Biology |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.biochi.2012.09.027 |
| Field | Genetics and molecular biology |
| Keywords | Apoptosis; Histones; HP1; Epigenetics; Chromatin |
| Description | Apoptotic bodies are the most condensed form of chromatin. In general, chromatin structure and function are mostly dictated by histone post-translational modifications.HP1 mobility in apoptotic cells appeared to be unique because limited exchange after photobleaching was observed for other epigenetically important proteins, including GFP-JMJD2b histone demethylase (similar to 10% fluorescence recovery) or Polycomb group-related GFP-BMI1 protein (similar to 20% fluorescence recovery). These findings imply a novel fact that only certain subset of proteins in apoptotic bodies is dynamic. |
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