Acute toxoplasmosis-etiological factor for development of Hodgkin's lymphoma?

• Authors: SNOPKOVÁ Svatava; POHANKA Miroslav; POLÁK Pavel; HAVLÍČKOVÁ Kateřina; JARKOVSKÝ Jiří; MOULIS Mojmír; ŠTROBLOVÁ Hana; HUSA Petr
• Year of publication: 2013
• Type: Article in Periodical
• Magazine / Source: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.3109/00365548.2013.807937
• Field: Epidemiology, infectious diseases and clinical immunology
• Keywords: Hodgkin's lymphoma; HIV; latent membrane protein; surface antigen GRA1; toxoplasmosis
• Description: The case of an HIV-positive man treated for acute toxoplasmosis with no traces of malignancy is reported. A second lymph node extirpation was performed after 5 months, which identified the presence of Hodgkin and Reed-Sternberg (HRS) cells. This case suggests that toxoplasmosis may cause changes in the regulation of surrounding cells and induce neoplastic proliferation.