Publication details
Antitrombin
| Title in English | Antithrombin |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | antithrombin; inherited deficiency; thromboembolic disease; laboratory examination |
| Description | Antithrombin is one the most important serine protease inhibitors (termed the serpin family), especially of thrombin and factor Xa. Its inherited deficiency is associated with an increased risk of venous thrombosis, pulmonary embolism and thrombosis in atypical localizations. There are even a few reports about arterial thrombosis associated with this deficiency. Pregnancy complications can occur in women with antithrombin deficiency. We use Functional assays are used to determine antithrombin (inhibitory) activity in the laboratory. The antigenic assay is used only to define the type of deficiency in the case of impaired antithrombin activity. FXa inhibition-based antithrombin assays appear to be the most widely used routine method. It is important to realize that it is possible that not all type II deficiencies can be detected using this assay as various defects have different findings and the results can in some cases be within normal range. In such cases, the diagnosis can be made only by genetic analysis. |