Publication details
HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women
| Authors | |
|---|---|
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Virchows Archiv |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1007/s00428-013-1511-4 |
| Field | Other medical specializations |
| Keywords | Cervix; Dysplasia; CIN III; HPV; Vaccination |
| Description | HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination. |