Publication details
A MATHEMATICAL MODEL OF RAT VENTRICULAR CARDIOMYOCYTE WITH A NOVEL DESCRIPTION OF INTRACELLULAR AND T-TUBULAR Ca2+ DYNAMICS
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Engineering mechanics |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | cardiac cell; intracellular Ca2+ dynamics; t-tubule; quantitative modelling |
| Description | In this paper, we present a novel quantitative description of intracellular and t-tubular Ca2+ dynamics in a model of rat cardiac ventricular myocyte. In order to simulate recently published data, the model incorporates t-tubular and peripheral dyads and intracellular subspaces, segmentation of the t-tubular luminal volume, reformulation of the inactivation properties of t-tubular and peripheral L-type calcium current (ICa) and a description of exogenous Ca2+ buffer function in the intracellular space. The model is used to explore activity-induced changes of ion concentrations in the intracellular and t-tubular spaces and their role in excitation – contraction coupling in ventricular myocytes. |