The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

• Authors: MALČÍKOVÁ Jitka; STALIKA Evangelia; DAVIS Zadie; PLEVOVÁ Karla; TRBUŠEK Martin; MANSOURI Larry; SCARFO Lydia; BALIAKAS Panagiotis; GARDINER Anne; SUTTON LA; FRANCOVA Hana Skuhrová; AGATHANGELIDIS Andreas; ANAGNOSTOPOULOS Achilles; TRACY Ian; MAKRIS Antonis; ŠMARDOVÁ Jana; GHIA Paolo; BELESSI Chrysoula; GONZALEZ David; ROSENQUIST Richard; OSCIER David; POSPÍŠILOVÁ Šárka; STAMATOPOULOS Kostas
• Year of publication: 2014
• Type: Article in Periodical
• Magazine / Source: British Journal of Haematology
• MU Faculty or unit: Central European Institute of Technology
• Web: http://onlinelibrary.wiley.com/doi/10.1111/bjh.12893/abstract
• Doi: http://dx.doi.org/10.1111/bjh.12893
• Field: Oncology and hematology
• Keywords: chronic lymphocytic leukaemia; immunoglobulin genes; stereotyped B cell receptors; TP53 mutations; prognosis

Attached files

• ZVV_2014_143_1216535_The_frequency_of_TP53.pdf

• Description: In chronic lymphocytic leukaemia (CLL) tumour initiation and progression are linked to the interplay between cellextrinsic and cell-intrinsic mechanisms. Cell-extrinsic mechanisms relate to the crosstalk of CLL cells with their microenvironment through various receptors, including the B-cell receptor (BcR).

Related projects

• SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny
• CEITEC - Central European Institute of Technology
• Molekulární charakterizace B buněčných receptorů a jejich vztah k evoluci genetických změn u chronické lymfocytární leukémie
• Časná identifikace CLL pacientů s dosud nevyselektovanými mutacemi v proteinu p53