Publication details
Prediktivní hodnota intenzity eozinofilního infiltrátu v nosních polypech
| Title in English | The predictive value of the intensity of eosinophilic infiltration in nasal polyps |
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| Authors | |
| Year of publication | 2012 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | In a study group of 94 patients operated on for bilateral nasal polyposis between 1998-2005, tissue eosinophilia was determined from polyp tissue samples. The mean value of tissue eosinophilia was 38,8 Eo/HPF (Me 32,5, Q0,25,75 = 14,58). Through analysis of a histogram curve of eosinophil infiltration intensity of patients in the follow-up study group, a tissue eosinophilia threshold value of 40Eo/HPF was determined and the patients were divided into two subgroups. In the first subgroup of patients with a value of eosinophilia up to 40Eo/HPF, there was a markedly lower percentage of recurrence (about 8%) in comparison with the second subgroup of patients with tissue eosinophilia higher than 40 Eo/HPF where recurrence occurred in more than half of patients (53%).The median value of the recurrence-free interval was significantly lower in the group of patients with higher tissue eosinophilia (33 months) as compared with the second group (51 months). Thus it has been proved that determination of tissue eosinophilia is of predictive significance and it can valuably contribute to the assessment of postoperative NP recurrence risk and thereby to the determination of an appropriate postoperative management |