Publication details
Myeloproliferativní neoplazie
| Title in English | Myeloproliferative neoplasms |
|---|---|
| Authors | |
| Year of publication | 2015 |
| Type | Chapter of a book |
| MU Faculty or unit | |
| Citation | |
| Description | Myeloproliferative neoplasms (MPN) are a group of diseases that affect normal blood cell production in the bone marrow in terms of one or more blood cell types overproduction. They are divided according to presence of specific chromosomal abnormality, Philadelphia (Ph) chromosome, to chronic myeloid leukemia (CML), which is Ph chromosome positive, and to a group of so called Ph chromosome negative MPNs, which comprises several distinguished disorders: chronic neutrophilic leukemia, polycythemia vera, essential thrombocytemia, primary myelofibrosis, chronic eosinophilic leukemia, mastocytosis, and unclassified MPN. The presented book chapter provides for comprehensive review of current epidemiology, clinical presentation, diagnostics, prognosis, therapy and its efficacy monitoring for the patients with CML as well with Ph negative MPN. |