Publication details
Cyklofosfamid následovaný busulfanem jako přípravný myeloablativní režim před alogenní transplantací krvetvorných buněk u 20 pacientů s akutní myeloidní leukémií: toxicita a efektivita
| Title in English | Cyclophosphamide following busulfan as conditioning for allogeneic hematopoietic stem cell transplantation in 20 patients with acute myeloid leukemia |
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| Authors | |
| Year of publication | 2015 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Busulfan (BU) followed by cyclophosphamide (CY) is commonly used myeloablative conditioning regimen in allogeneic hematopoetic stem cell transplantation, limitation of this approach is non-hematological toxicity. According to some authors, reversed order of CY and BU has got less liver toxicity and better outcomes. Our experience with combination CY/BU in cohort 20 patients with acute myeloid leukemia was presented. Conditioning CY/BU provides combination of effective disease control (90% of complete response) and acceptable toxicity, no case of veno-occlusive disease occured. Event-free survival and overal survival at 2 years from transplantation in our cohort of patients were 62% and 70%, respectively. |