Publication details
Leptin and Ventilation in Heart Failure Response
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Chest |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1378/chest.15-0326 |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | Leptin; Heart Failure |
| Description | We appreciate the comments of Drs Javaheri and Schwartz about our article in CHEST . 1 Our study was observational, and, as such, we cannot comment on causality regarding leptin and ventilatory drive. Furthermore, caution seems indicated when extrapolating fi ndings from ob/ob mice to human heart failure (HF). First, ob/ob mice are primarily a model of obesity, whereas chronic HF is frequently associated with cachexia. Second, leptin has been shown to infl uence lung development, 2 which may aff ect ob/ob mice but not patients with HF who experience leptin defi ciency only in adulthood. Third, in knock-out animal models, com pensatory mechanisms may alter normal physiologic controls and thereby not produce the expected effects of gene deletion. |