Publication details
Imunologické aspekty moderní léčby roztroušené sklerózy
| Title in English | Immunologic aspects of modern multiple sclerosis therapy |
|---|---|
| Authors | |
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Klinická imunológia a alergológia |
| MU Faculty or unit | |
| Citation | |
| Field | Epidemiology, infectious diseases and clinical immunology |
| Keywords | multiple sclerosis; immunomodulation therapy; autoimmunity; vaccination; depletion |
| Description | Multiple sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous system through demyelination and neurodegeneration. Autoreactive lymphocytes penetrate the blood-brain barrier to attack the nervous system. Fingolimod was approved as the first oral treatment for relapsing forms of MS. Its active metabolite, formed by in vivo phosphorylation, modulates sphingosine 1-phosphate receptors (SIPRs) and retains autoreactive lymphocytes in lymph nodes. It means unique mechanism of action which is different from the other drugs. By the laboratory monitoring of immunotherapy in patients with MS it is necessary to recognize depletion versus lymphocyte compartmentalization. Assessment of differential blood count (WBC) is a sensitive laboratory test for monitoring of patients treated with modern forms of multiple sclerosis therapy. |