Thermostable FGF2 Polypeptide, Use Thereof

• Authors: DVOŘÁK Petr; KREJČÍ Pavel; BÁLEK Lukáš; EISELLEOVÁ Lívia; KONEČNÁ Žaneta; DVOŘÁK Pavel; BEDNÁŘ David; BREZOVSKÝ Jan; ŠEBESTOVÁ Eva; CHALOUPKOVÁ Radka; ŠTĚPÁNKOVÁ Veronika; VAŇÁČEK Pavel; PROKOP Zbyněk; DAMBORSKÝ Jiří; BOSÁKOVÁ Michaela
• Year of publication: 2020
• Type: Patent
• MU Faculty or unit: Faculty of Science
• Publisher: European Patent Office
• State: Germany
• Patent's number: EP3380508
• Web: https://worldwide.espacenet.com/patent/search/family/054754475/publication/EP3380508B1?q=pn%3DEP3380508B1
• Description: The present invention relates to engineered Fibroblast Growth Factor 2 (FGF2, bFGF) having improved thermal stability compared to the wild-type and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. The present invention further relates to a culture medium comprising FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.

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