A genome-wide association study of marginal zone lymphoma shows association to the HLA region

• Authors: VIJAI Joseph; WANG Zhaoming; BERNDT Sonja I.; SKIBOLA Christine F.; SLAGER Susan L.; SANJOSE Silvia de; MELBYE Mads; GLIMELIUS Benght; BRACCI Paige M.; CONDE Lucia; BIRMANN Brenda M.; WANG Sophia S.; BROOKS-WILSON Angela R.; LAN Qing; BAKKER Paul I.W.; VERMEULEN Roel C.H.; PORTLOCK Carol; ANSELL Stephen M.; LINK Brian K.; RIBY Jacques; NORTH Kari E.; GU Jian; HJALGRIM Henrik; COZEN Wendy; BECKER Nikolaus; TERAS Lauren R.; SPINELLI John J.; TURNER Jenny; ZHANG YaweiW; PURDUE Mark P.; GILES Graham G.; KELLY Rachel S.; ZELENIUCH-JACQUOTTE Anne; ENNAS Maria Grazia; MONNEREAU Alain; BERTRAND Kimberly A.; ALBANES Demetrius; LIGHTFOOT Tracy; YEAGER Meredith; CHUNG Charles C.; BURDETT Laurie; HUTCHINSON Amy; LAWRENCE Charles; MONTALVAN Rebecca; LIANG Liming; HUANG Jinyan; MA Baoshan; VILLANO Danylo J.; MARIA Ann; CORINES Marina; THOMAS Tinu; NOVAK Anne J.; DOGAN Ahmet; LIEBOW Mark; THOMPSON Carrie A.; WITZIG Thomas E.; HABERMANN Thomas M.; WEINER George J.; SMITH Martyn T.; HOLLY Elizabeth; JACKSON Rebecca D.; TINKER Lesley F.; YE Yuanging; ADAMI Hans-Olov; SMEDBY Karin E.; DE ROOS Anneclaire; HARTGE Patricia; MORTON Lindsay M.; SEVERSON Richard K.; BENAVENTE Yolanda; BOFFETTA Paolo; BRENNAN Paul; FORETOVÁ Lenka; MAYNADIE Marc; MCKAY James; STAINES Anthony; DIVER W. Ryan; VAJDIC Claire M.; ARMSTRONG Bruce K.; KRICKER Anne; ZHENG TongzhangZ; HOLFORD Theodore R.; SEVERI Gianluca; VINEIS Paolo; FERRI Giovanni M.; RICCO Rosalia; MILIGI Lucia; CLAVEL Jacqueline; GIOVANNUCCI Edward; KRAFT Peter; VIRTAMO Jarmo; SMITH Alex; KANE Eleanor; ROMAN Eve; CHIU Brian C.H.; FRAUMENI Joseph F.; WU Xifeng; CERHAN James R.; OFFIT Kenneth; CHANOCK Stephen J.; ROTHMAN Nathaniel; NIETERS Alexandra
• Year of publication: 2015
• Type: Article in Periodical
• Magazine / Source: Nature Communications
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1038/ncomms6751
• Field: Oncology and hematology
• Keywords: Marginal zone lymphoma; non-Hodgkin lymphoma
• Description: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.