Publication details
The Synthesis of Two Regioisomeric Aldehydes with Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Synthesis |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1055/s-0035-1561428 |
| Field | Organic chemistry |
| Keywords | dipolar cycloadditions; benzothiophenes; polycycles; heterocycles; azomethine ylides; |
| Description | The paper describes synthesis of two regioisomeric 2-amino-3-formyl and 3-amino-2-formyl substituted derivatives of tetrahydrobenzo[b] thiophene and their preparation for subsequent thermally-initiated reactions with secondary amines for generation of azomethine ylides; these azomethine ylides entered into intramolecular 1,3-dipolar cycloadditions. In this way, two series of new fused heterocyclic compounds were prepared, having three stereogenic centres. The compounds were identified and their structures determined. |