Publication details
Dlouhé nekódující RNA u mnohočetného myelomu
| Title in English | Long non-coding RNAs in multiple myeloma |
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| Authors | |
| Year of publication | 2016 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
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| Description | Introduction Multiple myeloma (MM) is the second most common hematological malignancy in the world. It is characterized by increasing rate of various genetic mutations and dysregulated pathways. This work aims to find out if this observed dysregulation may be al least partly caused by a subgroup of non-coding RNAs, so-called long non-coding RNA molecules (lncRNA). These molecules are over 200 nt long, primarily localized in the nucleus, and it seems increasingly obvious that lncRNAs play a role in variety of cell processes, such as proliferation, differentiation and apoptosis. Also, it seems that these lncRNAs have a crucial role in the pathogenesis of a wide range of human diseases, including cancer. Therefore, it is very likely they contribute to tumor transformation and disease progression in MM. Conclusion Altogether, our first observations demonstrate that cellular lncRNA UCA1, NEAT1 and BDNF-AS may be involved in pathophysiological processes occurring in MM cells and prompt further studies in this field. |
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