Publication details

Je nutno revakcinovat proti viru hepatitidy B při poklesu titru anti-HBs protilátek pod 10 IU/l?

Title in English Is it necessary to revaccinate against hepatitis B virus when the titer of anti-HBs drops below 10 IU/L?
Authors

POLÁK P. HUSA Petr SMEJKAL Petr KAMELANDER J. CHLUPOVÁ Gabriela PENKA Miroslav

Year of publication 2016
Type Article in Periodical
Magazine / Source Klinická mikrobiologie a infekční lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Epidemiology, infectious diseases and clinical immunology
Keywords viral hepatitis B; revaccination; anti-HBs titer
Description Viral hepatitis B still represents a major epidemiological issue worldwide. After recombinant vaccine administration, a titer of anti-HBs antibodies > 10 IU/L has long been considered to be seroprotective. Persons without this antibody level after complete vaccination are referred to as non-responders. A progressive decline in anti-HBs levels over years is also commonly seen in responders. Recently, there has been increasing evidence that the titer of anti-HBs > 10 IU/L does not provide 100% protection against infection and clini¬cally manifest illness. Additionally, an important role of cellular immune memory has been demonstrated - without any correlation with anti-HBs titer. Based on current knowledge, there is no need for regular anti-HBs titer testing or booster vaccination in immu-nocompetent individuals with anti-HBs < 10 IU/L. At present, regular serological testing and, if need be, revaccination to maintain anti-HBs > 10 IU/L are recommended in immunocompromised persons and after liver transplantation.

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