Publication details
Dynamic phenotype: An individual growth model based on physiological principles
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Introduction: Dynamic Phenotype is a three-component parametric model which focuses on individual growth. Its mathematical foundation lies in the physiological principles of growth – the balance between anabolic and catabolic processes. The model provides output variables with clear biological interpretation and can be used to calculate the amount of energy utilized for growth at any point of the curve. Material: Model growth curves of 157 boys and girls were constructed using Dynamic Phenotype approach. Participants were born between 1991 and 1992 in Brno (CZ) and were followed longitudinally until 19 years of age. Methods: Model application and utilization is demonstrated on 157 model growth curves. The modeled curve is combined from three components; Infancy, Childhood and Puberty. I component is modeled by an exponential (Gompertz) function while C and P components are modeled by separate logistical (Verhulst) functions. Results: All 157 growth curves created based on empirical longitudinal data using DP fit empirical data with 95 % confidence. Several DP utilization possibilities were tested successfully: • individual growth formulas (numerical classification 1 – 5 by Lebl and Krásničanová) agreement with DP output parameters • sexual maturation and its association with P component onset • for inter-individual comparisons summary graphical display (10 growth curves in one chart) was successfully used Dynamic Phenotype is a reliable modelling and analytical method based on physiological principles. It has been proven that it fits empirical data with 95 % confidence and can be used to model individual growth and analyze it from different perspectives. |