Publication details

The 2011-2012 pilot European Society of Cardiology Sentinel Registry of Transcatheter Aortic Valve Implantation: 12-month clinical outcomes

Authors	GILARD Martine SCHLÜTER Michael SNOW Thomas M. DALL´ARA Gianni ELTCHANINOFF Helene MOAT Neil GOICOLEA Javier USSIA Gian Paolo KALA Petr WENAWESER Peter ZEMBALA Marian NICKENIG Georg PRICE Susanna BARRERO Eduardo Alegria IUNG Bernard ZAMORANO Pepe SCHULER Gerhard CORTI Roberto ALFIERI Ottavio PRENDERGAST Bernard LUDMAN Peter WINDECKER Stephan SABATE Manel WITKOWSKI Adam DANENBERG Haim SCHROEDER Ervin ROMEO Francesco MACAYA Carlos DERUMEAUX Genevieve LAROCHE Cécile PIGHI Michele SERDOZ Roberta MARIO Carlo Di
Year of publication	2016
Type	Article in Periodical
Magazine / Source	Eurointervention
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.4244/EIJV12I1A15
Field	Cardiovascular diseases incl. cardiosurgery
Keywords	aortic stenosis; registry; survival; transcatheter aortic valve implantation (TAVI)
Description	Aims: Our aim was to assess one-year outcomes of patients enrolled in the pilot European Sentinel Registry of Transcatheter Aortic Valve Implantation (TAVI). Methods and results: One-year outcomes of 4,571 patients (81.4 +/- 7.2 years, 2,291 [50.1%] male) receiving TAVI with the SAPIEN XT (57.3%) or CoreValve prosthesis at 137 European centres were analysed using Kaplan-Meier and Cox proportional hazards regression techniques. At one year, 3,341 patients were alive, 821 had died, and 409 were lost to follow-up. Of 2,125 patients who underwent functional assessment, 1,916 (90%) were in New York Heart Association (NYHA) Class I/II at one year, with functional improvement from baseline noted in 1,682 patients (88%). One-year survival based on 4,564 patients was estimated at 79.1%. Independent baseline predictors of mortality were increasing age and logistic EuroSCORE, the presence of NYHA III/IV, chronic obstructive pulmonary disease, and atrial fibrillation. Female gender was associated with a 4% survival benefit at one year. Vascular access routes other than transfemoral were associated with poorer survival. Procedural failure and major periprocedural complications had an adverse impact on survival. Conclusions: Contemporary European experience attests to the effectiveness of routine TAVI in unelected elderly patients.