Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction

• Authors: KOUDELKA Adolf; AMBROŽOVÁ Gabriela; KLINKE Anna; FIDLEROVÁ Táňa; VEREŠČÁKOVÁ Hana; KUCHTA Radek; RUDOLPH Tanja K; KADLEC Jaroslav; KUCHTOVA Zdenka; WOODCOCK Steven R.; FREEMAN Bruce A.; KUBALA Lukáš; PEKAROVÁ Michaela
• Year of publication: 2016
• Type: Article in Periodical
• Magazine / Source: Cardiovascular Drugs and Therapy
• MU Faculty or unit: Faculty of Science
• Web: http://link.springer.com/article/10.1007/s10557-016-6700-3
• Doi: http://dx.doi.org/10.1007/s10557-016-6700-3
• Keywords: Nitro-oleic acid; Asymmetric dimethylarginine; Hypoxia; Pulmonary hypertension; Human pulmonary artery endothelial cell
• Description: Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO2), an exemplary nitro-fatty acid (NO2-FA), in human pulmonary artery endothelial cells (HPAEC) under the influence of hypoxia or ADMA.