Publication details
Trombofilní stavy v těhotenství
| Title in English | Thrombophilic conditions during pregnancy |
|---|---|
| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Anesteziologie a intenzivní medicína |
| MU Faculty or unit | |
| Citation | |
| Field | Other medical specializations |
| Keywords | pregnancy; thrombophilia; prophylaxis; anaesthetic managemenent |
| Description | The risk of venous thromboembolic events is high during pregnancy due to both physiologic changes of pregnancy and the additional impact of the inherited and acquired thrombophilias. The women with thrombophilia are at increased risk, not only of pregnancy-related venous thromboembolism (VTE), but also other pregnancy complications, including early and late pregnancy loss, intrauterine growth restriction, placental abruption, and pre-eclampsia. Depending on the type of thrombophilia, personal and family history of VTE and history of pregnancy complications prophylactic treatment with low molecular weight heparin or unfractionated heparin is recommended. For women with thrombophilia and history of pregnancy complications combination of low dose aspirin and heparin can increase probability of live birth. On the other hand, pregnant women on prophylactic or therapeutic anticoagulation require an individualized delivery plan that addresses obstetrical, anesthetic, and thrombotic concerns. |