Publication details
A novel method for heterocyclic amide–thioamide transformations
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Beilstein Journal of Organic Chemistry |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-13-20.pdf |
| Doi | http://dx.doi.org/10.3762/bjoc.13.20 |
| Field | Organic chemistry |
| Keywords | heterocyclic amides; heterocyclic thioamides; N-cyclohexyl dithiocarbamate cyclohexylammonium salt; novel thiating agent; thiation |
| Description | In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields. |