Publication details

In vitro stanovení radiosenzitivity nádorů hlavy a krku

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Title in English In vitro radiosensitivity assesment in head and neck cancer
Authors

HORÁKOVÁ Zuzana BINKOVÁ Hana FALK M. MASAŘÍK Michal FALKOVÁ I. DEPEŠ D. GUMULEC Jaromír BAČÍKOVÁ A. PAGÁČOVÁ E. KOSTŘICA Rom

Year of publication 2016
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Head and neck tumours are agressively growing and the oncological treatment often results in patient's mutilation. Thus recently the non-surgical treatment (radiotherapy) is prefered. The effectivity of the first choice therapy is crucial for the treatment results. However, more than 50% of the tumours are not radio-sensitive enought. Unfortunately, still any sensitivizy marker for useful pre treatment radiosensitivity assesment is missing. Aim of the study is to evaluate the effect of irradiation in vitro on cell lines (cultivated from tissue samples taken from patients prior to treatment). After an experimental irradiation , damage of the DNA is estimated (number of the DNA double strand breaks) and the repair dynamic and capacity. The results will be correlated to the tumour treatment response.
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