Publication details
Dermatomyozititida asociovaná s cytomegalovirovou infekcí
| Title in English | Dermatomyositis associated with cytomegalovirus infection |
|---|---|
| Authors | |
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Česká dermatovenerologie |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | inflammatory myopathies; dermatomyositis; cytomegalovirus; methylprednisolon; methotrexate |
| Description | Inflammatory myopathies are acquired autoimmune diseases, clinically characterized by weakness and soreness of muscles and elevated muscle enzymes - creatine kinase and lactate dehydrogenase, his-topathologically by myonecrosis and mo- nonuclear inflammatory infiltrate. The most common inflammatory myopathies are dermatomyositis, polymyositis, and inclusion body myositis. Dermatomyositis is a rare inflammatory disease with autoimmune features marked by muscle weakness and a distinctive skin rash - a heliotrope rash on the face, fleeting erythema on the extensor surfaces, erythematous papules over the small knuckles (Gottron's sign) etc. Other frequent symptoms are muscle contractu-res, subcutaneous calcification, intestinal ulceration. Dermatomyositis affects adults and children alike. In children, the disease most often appears between 5 and 15 years of age. In adults, dermatomyositis usually occurs from the late 30s to early 60s. Dermatomyositis affects more females than males. The case of dermatomyositis in a 37-year old woman with acute cytomegalovirus infection, succesfully treated with combination od methylprednisolon and me-thotrexate, is described in the presented case study. |