Publication details
Vybrané změny a zapojení imunitního systému člověka při infekci Borrelia burgdorferi sensu lato; prevalence borrelií a další infekce v souboru klíšťat
| Title in English | Selected changes and the involvement of human immune system during infection with Borrelia burgdorferi sensu lato; the prevalence of borreliae and other infections in a set of ticks |
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| Authors | |
| Year of publication | 2017 |
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| Citation | |
| Description | Borrelia burgdorferi sensu lato is a spirochaetal bacteria and a causative agent of Lyme borreliosis. The immune processes, which eliminate a pathogen from the organism, are quite efficient. During borrelial infection, both inate and adaptive imunity are being involved. Borrelia uses various mechanisms to avoid these processes, such as antigen variation and modulation and the resistance to complement. Although the human immune response is quite effective, the bacteria is able to persist in the organism despite of antibiotic therapy for a long time and it is able to cause typical manifestations of Lyme borreliosis. A set of 1742 collected ticks was examined using PCR method for the presence of sequences specific for selected pathogenic microorganisms. The genetic information of four zoonotic pathogens was detected: Borrelia burgdorferi sensu lato (24.2%), Ehrlichia chaffeensis (1%), Francisella tularensis (2.3%) and Rickettsia sp. (3.7%). These results show the risk of transmission of multiple pathogens to the host during a tick blood intake. |