Evolution and functions of SMC complexes: new SMC5/6 insights

• Authors: PALEČEK Jan; GRUBER Stephan; VONDROVÁ Lucie; ADAMUS Marek; ZÁBRADY Kateřina; JURČIŠINOVÁ Lenka; CRABBEN Saskia N van der; HENNUS Marije P; MCGREGOR Grant; RITTER Deborah I; LEHMANN Alan R; OLIVER Antony W; KOZLÍKOVÁ Barbora; PLON Sharon E; MURRAY Johanne M; HAAFTEN Gijs van
• Year of publication: 2016
• Description: The SMC (structure maintenance of chromosome) complexes are conserved from bacteria to humans (SMC/ScpAB and MukBEF in prokaryotes; cohesin, condensin and SMC5/6 in eukaryotes). They are critical for DNA replication, chromosome compaction and segregation, genome maintenance, and regulation of gene expression. We described marked structural similarities between bacterial SMC/ScpAB and eukaryotic SMC5/6 complexes (particularly their kite subunits). We discovered several important features of SMC5/6 kite subunits: their role in structural organization of the SMC5/6 complex, their DNA-binding ability, their evolution from bacteria to novel mammalian MAGE protein superfamily and new chromosome breakage syndrome associated with human Nse3-kite subunit mutations.

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